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. 2012 May 3;8(5):e1002496. doi: 10.1371/journal.pcbi.1002496

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Penfold et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) During mitosis the nucleus divides and centromeres move towards the microtubule organiser (spindle pole body in S. cereveisiae). (B) The centromeres remain clustered and close to the nuclear envelope in the Rabl configuration. (C) During early meiosis the telomeres become attached via SUN/KASH proteins (not shown) to the nuclear envelope and then (D) cluster near the microtubule organising centre in the bouquet configuration.