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. 2012 May 3;8(5):e1002673. doi: 10.1371/journal.pgen.1002673

Figure 1. Ammonium and glucose are preferred nitrogen and carbon sources in filamentous fungi.

Figure 1

(A) Nitrogen metabolite repression (NMR) ensures the preferential utilization of ammonium (NH4 +) or L-glutamine as nitrogen sources by modulating the activity of a GATA family transcriptional activator (AreA in Aspergillus nidulans) necessary for the expression of genes involved in assimilating and utilizing alternative nitrogen sources (Alt N). (B) In the presence of glucose, carbon catabolite repression (CCR) acts via a negatively-acting transcriptional repressor (CreA in Aspergillus nidulans) to prevent the expression of genes required for utilizing alternative carbon sources (Alt C).