Figure 4.

Cell cycle analysis of granulosa cells by flow cytometry. A, Granulosa cells treated with 25 and 50 μmol/L SP600125 at sixth hour after aphidicolin release exhibit delay and arrest at G2/M transition, respectively. B, Percentage of cells at G2 during G2/M transition in control and JNK inhibitor groups. There is a dose-dependent increase (accumulation) of cells at G2 after treatment of JNK inhibitors, showing a block in cell cycle progression during G2/M transition. JNK indicates c-Jun N-terminal kinase.