Table 1.
The Number of Follicles, the Mean Diameter of Follicles on Days 0 and 6, and the Mean Percentage of Growth for Control and JNK Inhibitor Groups After 6 Days of Culture in Matrigela
| Groups | N | Follicle Diameter, Mean ± SEM (Day 0) | Follicle Diameter, Mean ± SEM (Day 6) | % Growth Mean ± SEM |
|---|---|---|---|---|
| Control (DMSO) | 13 | 120.6 ± 1.4 | 208.1 ± 7.4 | 72.1 ± 5.4b,c |
| SP600125 (25 μmol/L) | 10 | 130.9 ± 11 | 161.1 ± 15.1 | 22.8 ± 1.4 b |
| SP600125 (50 μ mol/L) | 11 | 125.8 ± 12.6 | 141.1 ± 20.7 | 9.75 ± 6.0 b |
| SP600125 (100 μ mol/L) | 12 | 113.6 ± 9.9 | 103.1 ± 5.3 | −8.02 ± 4.1 c |
| AS601245 (25 μ mol/L) | 9 | 145.5 ± 9.6 | 169.1 ± 13.2 | 16.2 ± 12.9 b |
| AS601245 (50 μ mol/L) | 10 | 107.2 ±19.4 | 117.2 ± 23.8 | 9.23 ± 6.4 b |
| AS601245 (100 μ mol/L) | 10 | 126.9 ± 10.7 | 113.2 ± 9.9 | −10.5 ± 1.8 c |
Abbreviations: JNK, c-Jun N-terminal kinase pathway; DMSO, dimethyl sulfoxide.
a Note the dose-dependent decrease in growth of preantral follicles treated with JNK inhibitors SP600125 and AS6012145 at 25, 50, and 100 μ mol/L concentrations.
b P < .01.
c P < .0001.