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. 2012 May 3;7(5):e36397. doi: 10.1371/journal.pone.0036397

Figure 1. A53Tα-syn overexpression does not affect [DA]o evoked by a single stimulus pulse.

Figure 1

(a) Profiles of mean [DA]o± SEM versus time, after single pulse stimulation (arrow). There was no significant difference in [DA]o between genotypes, at either age or in either region (n = 15–40 (CPu), n = 6–14 (NAc)). There was also no significant difference in mean peak [DA]o between 6–14 and 18–24 month mice of any genotype (n = 15–40 (CPu), n = 6–14 (NAc)). (b) Mean peak [DA]o± SEM evoked by a single pulse. (c) Cumulative distribution plots of peak [DA]o (µM) evoked by a single stimulation pulse. Curve fits are sigmoidal variable slope curves, R2>0.93. Curves are not significantly different between genotypes at 6–14 months in CPu or at either age in NAc, but are significantly different in CPu at 18–24 months. (d) Mean decay phases of concentration-matched DA transients in CPu do not differ between genotypes (n = 9–28).