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. 2012 Apr 26;8(4):e1002665. doi: 10.1371/journal.pgen.1002665

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Demarco et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Arrows represent functional or genetic interactions between molecules and do not imply physical interactions. A) TIAM-1 controls protrusive events downstream of UNC-40/DCC. Results presented here suggest that TIAM-1 acts downstream of UNC-40/DCC and CDC-42, and upstream of the Rac GTPases CED-10 and MIG-2, in ectopic lamellipodial and filopodia formation and attractive axon guidance. B) TIAM-1 and UNC-73/Trio might regulate distinct aspects of Rac function in UNC-40/DCC-mediated axon guidance. TIAM-1 might regulate Rac GTPases downstream of UNC-40/DCC involving cytoskeletal protrusive events. UNC-73/Trio might control Rac GTPases upstream of UNC-40/DCC in trafficking of UNC-40/DCC to the membrane [55], [62]. The dashed arrow indicates a potential feedback loop where by UNC-40/DCC might control its own membrane trafficking via UNC-73. Ig = immunoglobulin I domain; FNIII = fibronectin type III domain; TM = transmembrane domain; P1–P3 = conserved proline-rich domains; EVH1 = EVH1 domain; PDZ = PDZ domain; DH = Dbl-homology domain; PH = Pleckstrin homology domain.