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. 2012 Apr 26;8(4):e1002683. doi: 10.1371/journal.pgen.1002683

Figure 6. dZip1 expression modulation ameliorates the Aβ42-induced immediate memory loss.

Figure 6

(A) Expression of Aβ42 in fly brains induced an immediate memory loss compared with the control flies (elav-Gal4>UAS-Aβ42 vs. UAS-Aβ42) at 5-day-old. Both dZip1 OE and RNAi in Aβ42-expressing fly brains (elav-Gal4>UAS-Aβ42/UAS-dZip1 or elav-Gal4>UAS-Aβ42/UAS-dZip1-RNAi 1#) significantly ameliorated immediate memory loss. t-test, ***P<0.001. n = 8 PIs for each genotype. (B–C) Without expression of Aβ42, dZip1 OE and RNAi had no effects on immediate memory (elav-Gal4>UAS-dZip1 or elav-Gal4>UAS-dZip1-RNAi 1# vs. elav-Gal4), although dZip1 OE mildly increased the memory score. n = 6–7 as indicated. All behavior data are normalized to the control flies. Data are expressed as means ± SEM.