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Ni2+ blocks 5-hydroxytryptamine (5-HT)-mediated pulmonary arterial contraction. Bars indicate mean ± SEM of %T5-HT Control in the absence or presence of 10 mmol/L Ni2+ for arteries from normoxic (open) and LTH (solid) fetuses.**P < .01 denotes significant difference between the absence and presence of 10 mmol/L Ni2+ by an unpaired Student t test. LTH indicates long-term hypoxia; SEM, standard error of the mean.
