Table 3.
Expression of Adrenal Steroidogenic Enzymes in Maternal Adrenals on Day 21 of Gestationa
| Gene | Fold Change | P Value |
|---|---|---|
| CYP11B1 | −9.0 ± 0.03 | .001 |
| CYP11B2 | −5.9 ± 0.07 | .001 |
| ACTH-R (MC2) | −2.0 ± 0.11 | .05 |
| CYP11A1 | −2.3 ± 0.03 | .001 |
| HSD1 | 1.1 ± 0.15 | NS |
| HSD2 | −1.7 ± 0.29 | NS |
| GCR (NR3C1) | −1.2 ± 0.13 | NS |
| MCR (NR3C2) | 1.3 ± 0.45 | NS |
| STAR | −2.0 ± 0.10 | NS |
| CYP17A1 | −3.2 ± 0.13 | NS |
Abbreviations: CYP11B1, 11-beta hydroxylase; CYP11B2, aldosterone synthase; ACTH-R, ACTH receptor (MC2); CYP11A1, side chain cleavage enzymes; HSD, hydroxysteroid dehydrogenase; GCR (NR3C1), glucocorticoid receptor; MCR, mineralocorticoid receptor (NR3C2); CYP17A1, 17 alpha-hydroxylase.
a Negative numbers signify lower expression in MUN vs control dams. Values are expressed as mean fold change compared to control ± SEM. N = 4 control and 6 MUN dams.