Table 5.
Gene | Fold Change | P Value Male | Fold Change | P Value Female |
---|---|---|---|---|
CYP11B1 | −1.1 ± 0.07 | NS | −1.3 ± 0.06 | NS |
CYP11B2 | 1.5 ± 0.13 | .05 | 1.1 ± 0.10 | NS |
ACTH-R | 1.9 ± 0.57 | NS | 1.7 ± 0.22 | .02 |
CYP11A1 | 1.9 ± 0.5 | .001 | 1.3 ± 0.28 | .03 |
HSD1 | 2.9 ± 0.16 | .001 | −1.1 ± 0.09 | NS |
HSD2 | 1.1 ± 0.03 | NS | 1.0 ± 0.18 | NS |
GCR | 2.2 ± 0.008 | .001 | −1.3 ± 0.02 | .04 |
MCR | −1.1 ± 0.45 | NS | 1.1 ± 0.09 | NS |
STAR | 1.0 ± 0.19 | NS | −1.1 ± 0.06 | NS |
CYP17A1 | −1.5 ± 0.04 | NS | −2.3 ± 0.03 | .04 |
Ob-Ra | 2.9 ± 0.1 | .002 | 1.2 ± 0.03 | NS |
Ob-Rb | 2.5 ± 0.03 | .001 | 1.6 ± 0.05 | .001 |
Abbreviations: CYP11B1, 11-beta hydroxylase; CYP11B2, aldosterone synthase; ACTH-R, ACTH receptor (MC2); CYP11A1, side chain cleavage enzymes; HSD, hydroxysteroid dehydrogenase; GCR (NR3C1), glucocorticoid receptor; MCR, mineralocorticoid receptor (NR3C2); CYP17A1, 17 alpha-hydroxylase. a Values are expressed as mean fold change ± SEM compared to control. N = 4 males and 4 females.
a Values are expressed as mean fold change ± SEM compared to control. N = 4 males and 4 females.