Table 5.

Adrenal Steroidogenic Enzymes mRNA in 9-Month Adult Male and Female Offspring^a

Gene	Fold Change	P Value Male	Fold Change	P Value Female
CYP11B1	−1.1 ± 0.07	NS	−1.3 ± 0.06	NS
CYP11B2	1.5 ± 0.13	.05	1.1 ± 0.10	NS
ACTH-R	1.9 ± 0.57	NS	1.7 ± 0.22	.02
CYP11A1	1.9 ± 0.5	.001	1.3 ± 0.28	.03
HSD1	2.9 ± 0.16	.001	−1.1 ± 0.09	NS
HSD2	1.1 ± 0.03	NS	1.0 ± 0.18	NS
GCR	2.2 ± 0.008	.001	−1.3 ± 0.02	.04
MCR	−1.1 ± 0.45	NS	1.1 ± 0.09	NS
STAR	1.0 ± 0.19	NS	−1.1 ± 0.06	NS
CYP17A1	−1.5 ± 0.04	NS	−2.3 ± 0.03	.04
Ob-Ra	2.9 ± 0.1	.002	1.2 ± 0.03	NS
Ob-Rb	2.5 ± 0.03	.001	1.6 ± 0.05	.001

Abbreviations: CYP11B1, 11-beta hydroxylase; CYP11B2, aldosterone synthase; ACTH-R, ACTH receptor (MC2); CYP11A1, side chain cleavage enzymes; HSD, hydroxysteroid dehydrogenase; GCR (NR3C1), glucocorticoid receptor; MCR, mineralocorticoid receptor (NR3C2); CYP17A1, 17 alpha-hydroxylase. ^a Values are expressed as mean fold change ± SEM compared to control. N = 4 males and 4 females.

^a Values are expressed as mean fold change ± SEM compared to control. N = 4 males and 4 females.