Table 7.
Association of COMT Haplotype With Preterm Birth in African Americans
| SNPs | Maternal | Fetal | ||||
|---|---|---|---|---|---|---|
| Haplotype | Frequency | P Value | Haplotype | Frequency | P Value | |
| Two-marker sliding window haplotype analysisa | ||||||
| RS6269-RS4633 | G-T | 0.051 | .65 | G-T | 0.37 | .42 |
| RS4633-RS4818 | T-C | 0.35 | .75 | T-C | 0.30 | <.03 |
| RS4818-RS4680 | G-G | 0.21 | .79 | C-A | 0.29 | <.03 |
| Three-marker sliding window haplotype analysis | ||||||
| RS6269-RS4633-RS4818 | A-T-C | 0.30 | .63 | A-T-C | 0.30 | .10 |
| RS4680-RS4818-RS4633 | T-C-G | 0.08 | .23 | C-C-G | 0.44 | <.04 |
| Four-marker sliding window haplotype analysis | ||||||
| RS6269-RS4633-RS4818-RS4680 | G-C-G-G | 0.17 | .41 | A-T-C-A | 0.28 | .14 |
Abbreviations: COMT, catechol-O-methyltransferase; SNP, single-nucleotide polymorphism.
a PowerMarker and HaploView statistical softwares were used.