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Trophoblast vesicles are invasive. Vesicles for formed in the bioreactor for 7 days. The spheroids were then placed on a matrigel-coated cell culture dish for 36 hours. a, Vesicles can be seen at various positions throughout the matrix. The vesicles in focus (solid arrow) are closest to the objective while the vesicles varying in densities are farther away from the objective (dashed arrow). b, Cells left the vesicle and invaded through the membrane.
