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. 2011 Nov;18(11):1092–1102. doi: 10.1177/1933719111404609

Figure 6.

Figure 6.

Interleukin 1 (IL-1) signaling did not decrease lipopolysaccharide (LPS)-induced myeloperoxidase (MPO) expression in inflammatory cells in preterm fetal sheep. Assessments were made 2 days after intra-amniotic injections. a, Quantitation of MPO-expressing cells in the chorioamnion. b-d, Representative photomicrographs of chorioamnion immunostained with an anti-MPO antibody in fetuses exposed to (b) saline (controls), (c) intra-amniotic LPS, or (d) LPS + recombinant human IL-1 receptor antagonist (rhIL-1ra). The insets in panels c and d show inflammatory cells at a higher magnification (note the neutrophil morphology in most cells). Exposure to LPS increased MPO expressing inflammatory cells (arrow) in the chorion. Inhibition of IL-1 signaling did not modify LPS-induced changes (n = 4 animals/group; A indicates amnion; C = chorion; Scale bar 50 μm; * P < .05 compared to controls).