Skip to main content
. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: J Invest Dermatol. 2012 Feb 2;132(7):1869–1876. doi: 10.1038/jid.2011.463

Figure 5. IFN-γ neutralization prevents depigmentation and melanocyte-specific CD8+ T cell accumulation in the skin.

Figure 5

IFN-γ was neutralized through intraperitoneal injection of IFN-γ neutralizing antibody (500 μg) beginning 2 weeks after induction and twice weekly until scored at 5 weeks (error bars = mean +/− SEM, n=4 control, n=5 vitiligo, n=4 vitiligo + IFN-γ blockade). (a) Vitiligo Score is decreased by IFN-γ neutralization. (b–c) The effects of IFN-γ neutralizing antibody on the total numbers of melanocyte-specific CD8+ T cells in the ear (b) and in skin-draining lymph nodes (c).