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. Author manuscript; available in PMC: 2012 Nov 3.
Published in final edited form as: Nature. 2012 Mar 29;485(7396):62–68. doi: 10.1038/nature11030

Figure 4. REV-ERB ligands alter the pattern of circadian expression of metabolic genes in the liver, skeletal muscle and adipose tissue.

Figure 4

C57Bl6 mice were administered a single dose of SR9011 (100 mg/kg, i.p.) at CT0 and groups of animals (n=6) were sacrificed and gene expression assessed by QPCR. Graphs were double plotted. a, Expression of core clock genes from the liver of vehicle treated vs. SR9011 treated mice. b, Expression of metabolic genes from the liver of vehicle treated vs. SR9011 treated mice. c, Expression of metabolic genes from the skeletal muscle of vehicle treated vs. SR9011 treated mice. d, Expression of metabolic genes from the white adipose tissue (WAT) of vehicle treated vs. SR9011 treated mice. * indicates p<0.05. Error bars indicate mean ± s.e.m. and n=6–10 mice