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. Author manuscript; available in PMC: 2012 Nov 3.
Published in final edited form as: Nature. 2012 Apr 8;485(7396):128–132. doi: 10.1038/nature10988

Figure 4.

Figure 4

InsP3R activity is upregulated in diabetes. A. Hepatic CRE-luc and calcineurin activity in lean and db/db mice (*P < 0.001; n=5). B. Immunoblots showing relative amounts and phosphorylation of InsP3R family members in livers of ad libitum fed lean, db/db, or ob/ob mice. InsP3R phosphorylation at PKA or AKT sites indicated. C. Effect of RNAi-mediated depletion of InsP3Rs or calcineurin A on CRE-luc activity, gluconeogenic gene expression, and hepatic glucose production in db/db mice, determined by pyruvate tolerance testing (*P < 0.01; n=5).