Table 1.

Comparison of the prognostic value of the immune environment between nodal (DLBCL) and central nervous system (PCNSL) diffuse large B-cell lymphomas.

Tumor type	Cell type	Marker	Detection method	Prognosis value	Nb of cases	Tumor localization	Reference
INNATE
DLBCL	APCs (including tumor)	HLA-DR+	Immunohistochemistry	>0	414	Nodal (± extranodal sites)	Bernd et al. (2009)
	APCs (including tumor)	HLA class II	Immunohistochemistry	Not assessed	254	Nodal and extranodal including PCNSL	Riemersma et al. (2005)
	Macrophages	CD68+	Immunohistochemistry	No	176	Nodal (54%) and extranodal (46%)	Hasselblom et al. (2008)
	DCs	S100+	Immunohistochemistry	>0 if peritumoral	48	Nodal (54%) and extranodal (46%)	Chang et al. (2007)
	DCs	CD1a+	Immunohistochemistry	>0 if intratumoral	48	Nodal (54%) and extranodal (46%)	Chang et al. (2007)
	DCs	S100+/GILT+	Gene expression	Not assessed	176	Nodal	Monti et al. (2005)
	FDCs	CD23+	Immunohistochemistry	>0	414	Nodal (± extranodal sites)	Bernd et al. (2009)
	FDCs	CD21+	Immunohistochemistry	No*	66	Nodal (± extranodal sites)	van Imhoff et al. (2006)
PSNCL	M2 macrophages	CD68+ CD163+ CD204+ S100−	Immunohistochemistry	No	43	Brain	Komohara et al. (2011)
	M2 macrophages	CD68+ Factor XIII+ S100−	Immunohistochemistry	Not assessed	15–20	Brain	Kadoch et al. (2009)
	DCs	CD11c gene	Gene expression	Not assessed	23	Brain	Rubenstein et al. (2006)
ADAPTIVE
DLBCL	T-cells	Leu-2+	Immunohistochemistry	>0 (relapse-free survival)	82		Lippman et al. (1990)
	T-cells	CD45RO+	immunohistochemistry	>0	48	Nodal (54%) and extranodal (46%)	Chang et al. (2007)
	Th-cells (memory)	CD4+ HLA− DR+ CD45RO+	Flow cytometry	>0 if >20%	98	Nodal (± extranodal sites)	Ansell et al. (2001)
	T-cells	CD3+	Immunohistochemistry	No	195	Nodal (± extranodal sites) and extranodal	Hasselblom et al. (2007)
	CTLs	Granzyme B+	Immunohistochemistry	<0	70	Nodal	Muris et al. (2004)
	CTLs	TIA-1+ and/or perforin+	Immunohistochemistry	>0 if low number	195	Nodal (± extranodal sites) and extranodal	Hasselblom et al. (2007)
	CTLs	CD8+ Granzyme B+	Immunohistochemistry	Not assessed	254	Nodal and extranodal including PCNSL	Riemersma et al. (2005)
	Treg	Foxp3+	Immunohistochemistry	<0 in non-GC-DLBCL	270	Nodal	Tzankov et al. (2008)
	Treg	Foxp3+	Immunohistochemistry	>0 in GC-DLBCL	270	Nodal	Tzankov et al. (2008)
	Treg	Foxp3+	Immunohistochemistry	>0 if >2.3%	96	Nodal (± extranodal sites)	Lee et al. (2008)
	Treg	Foxp3+	Immunohistochemistry	No	195	Nodal (± extranodal sites) and extranodal	Hasselblom et al. (2007)
PCNSL	CTLs	CD8+ Granzyme B+	Immunohistochemistry	Not assessed	254	Nodal and extranodal including PCNSL	Riemersma et al. (2005)

Prognostic value of different immune cells is indicated by the color: green means good prognostic value, yellow means no prognostic value, red reflects bad prognostic value and white means not assessed.

APC, antigen-presenting cells; CTLs, cytotoxic T lymphocytes; DCs, dendritic cells; DLBCL, diffuse large B-cell lymphoma; FDC, follicular dendritic cells; GC, germinal center; PCNSL, primary central nervous system lymphoma; Th, helper T lymphocytes; Treg, regulatory T lymphocytes.

*Density of these cells was of no prognostic value but was associated to a better response to the treatment.