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. 2012 Jan;2(1):53–67. doi: 10.1002/brb3.33

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© 2012 The Authors. Published by Wiley Periodicals, Inc.

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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MOG antibody plus complement-induced demyelination. The spinal cord-derived culture at DIV40 was subjected to an autoimmune challenge by exposure to MOG antibody plus complement. Compared to the control (A and E), MOG antibody (B), or complement alone (C), MOG antibody plus complement induced a rapid and severe demyelination. Only a few myelin segments that were rather short and irregular could be found in the MOG antibody plus complement treatment at 24 h (D). At 48 h, only some myelin debris shown as small myelin basic protein (MBP)+ subjects could be detected (G), and they were no long detected at 96 h (H). In addition to demyelination, MOG antibody plus complement also lead to a progressive axonal degeneration (I–L). Scale bar: 50 μm (A–D and I–L); 30 μm (E–H).