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. 2012 Feb 29;81(10):1002–1014. doi: 10.1038/ki.2011.457

Table 1. Metabolic data of four groups at 16 weeks of experiment.

  Normal diet
High-fat diet
Groups WT SR-A−/− WT SR-A−/−
Body weight (g) 34.6±1.5 35.2±1.6 55.2±1.8a 54.5±1.7
BP (mm Hg) 92.0±11.2 91.1±8.9 94.2±10.3 93.2±10.7
Plasma Cr (μmol/l) 67.5±4.3 66.2±4.8 106.0±7.8a 82.4±6.5b
Plasma triglyceride (mmol/l) 1.31±0.31 1.24±0.44 2.58±0.53a 2.45±0.46
Plasma cholesterol (mmol/l) 2.35±0.43 2.42±0.36 6.73±0.62a 6.36±0.53
Plasma MCP-1 (μg/l) 125.1±6.7 127.0±10.3 294.0±11.2a 144.0±10.2b
Plasma IL-6 (μg/l) 109.43±6.3 111.28±9.5 445.3±15.6a 169.4±8.7b
Plasma TNF-α (μg/l) 69.50±4.8 69.20±4.5 144.6±10.9a 99.9±6.4b

Abbreviations: BP, blood pressure; Cr, creatinine; IL-6, interleukin-6; MCP-1, monocyte chemoattractant protein-1; SR-A, scavenger receptor A; SR-A−/−, SR-A deficiency mice; TNF-α, tumor necrosis factor-α WT, SR-A wild-type mice.

a

P<0.05 versus WT mice fed with normal diet.

b

P<0.05 versus WT mice fed high-fat diet.

Data are means±s.e.m.; n=12 in each group.