Table 1. Metabolic data of four groups at 16 weeks of experiment.
Normal diet |
High-fat diet |
|||
---|---|---|---|---|
Groups | WT | SR-A−/− | WT | SR-A−/− |
Body weight (g) | 34.6±1.5 | 35.2±1.6 | 55.2±1.8a | 54.5±1.7 |
BP (mm Hg) | 92.0±11.2 | 91.1±8.9 | 94.2±10.3 | 93.2±10.7 |
Plasma Cr (μmol/l) | 67.5±4.3 | 66.2±4.8 | 106.0±7.8a | 82.4±6.5b |
Plasma triglyceride (mmol/l) | 1.31±0.31 | 1.24±0.44 | 2.58±0.53a | 2.45±0.46 |
Plasma cholesterol (mmol/l) | 2.35±0.43 | 2.42±0.36 | 6.73±0.62a | 6.36±0.53 |
Plasma MCP-1 (μg/l) | 125.1±6.7 | 127.0±10.3 | 294.0±11.2a | 144.0±10.2b |
Plasma IL-6 (μg/l) | 109.43±6.3 | 111.28±9.5 | 445.3±15.6a | 169.4±8.7b |
Plasma TNF-α (μg/l) | 69.50±4.8 | 69.20±4.5 | 144.6±10.9a | 99.9±6.4b |
Abbreviations: BP, blood pressure; Cr, creatinine; IL-6, interleukin-6; MCP-1, monocyte chemoattractant protein-1; SR-A, scavenger receptor A; SR-A−/−, SR-A deficiency mice; TNF-α, tumor necrosis factor-α WT, SR-A wild-type mice.
P<0.05 versus WT mice fed with normal diet.
P<0.05 versus WT mice fed high-fat diet.
Data are means±s.e.m.; n=12 in each group.