Table 3. Metabolic data of the BMT mice at 16 weeks of dietary intervention.
Normal diet |
High-fat diet |
|||||
---|---|---|---|---|---|---|
Groups | WT to WT (n=6) | WT to SR-A−/− (n=6) | SR-A −/− to WT (n=7) | WT to WT (n=6) | WT to SR-A−/− (n=6) | SR-A −/− to WT (n=5) |
Body weight (g) | 33.4±3.5 | 34.2±2.5 | 34.1±2.5 | 54.9±3.6a | 55.5±3.4b | 55.3±4.7c |
BP (mm Hg) | 92.5±10.3 | 92.7±9.3 | 92.0±11.5 | 92.2±10.7 | 94.2±10.8 | 93.1±8.9 |
Plasma Cr (mol/l) | 62.5±5.3 | 66.5±6.4 | 63.5±4.7 | 110.4±6.5a | 106.0±7.8b | 96.2±8.5c,d,e |
Plasma triglyceride (mmol/l) | 1.33±0.56 | 1.41±0.61 | 1.35±0.36 | 2.55±0.41a | 2.58±0.63b | 2.54±0.94c |
Plasma cholesterol (mmol/l) | 2.45±0.48 | 2.39±0.63 | 2.49±0.46 | 6.76±0.93a | 6.79±0.69b | 6.72±0.76c |
Plasma MCP-1 (μg/l) | 129.1±9.2 | 126.1±8.7 | 128.9±9.7 | 279.0±10.2a | 264.0±11.2b | 167.0±10.3c,d,e |
Plasma IL-6 (μg/l) | 112.5±6.7 | 108.3±6.9 | 110.4±6.3 | 469.9±8.7a | 439.1±14.6b | 211.2±9.5c,d,e |
Plasma TNF-α (μg/l) | 73.5±6.9 | 69.0±7.8 | 68.5±7.1 | 159.9±6.8a | 174.6±10.1b | 99.20±14.6c,d,e |
Abbreviations: BMT, bone marrow transplantation; BP, blood pressure; Cr, creatinine; IL-6, interleukin-6; MCP-1, monocyte chemoattractant protein-1; SR-A, scavenger receptor A; SR-A−/−, SR-A deficiency mice; TNF-α, tumor necrosis factor-α WT, SR-A wild-type mice.
P<0.05 versus WT to WT BMT mice fed with normal diet.
P<0.05 versus WT to SR-A−/− BMT mice fed with normal diet.
P<0.05 versus SR-A−/− to WT BMT mice fed with normal diet.
P<0.05 versus WT to WT BMT mice fed with high fat diet.
P<0.05 versus WT to SR-A−/− BMT mice fed with high-fat diet.
Data are means±s.e.m.