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. 2012 Mar 6;31(8):2047–2059. doi: 10.1038/emboj.2012.54

Figure 2.

Figure 2

Comparison of human CD1d-LPC with other CD1d structures. (A) Human CD1d–LPC is shown in cyan compared with mouse CD1d presenting PC (Giabbai et al, 2005) (PDB ID: 1ZHN), shown in grey. Structures were aligned via the main-chain CA carbons of the heavy chains without ligand included. LPC in yellow and PC from the mouse structure in grey; the α2 helix has been omitted for clarity are shown. The sn1 and sn2 chains of the lipids are shown where present. Atoms are coloured as in Figure 1. (B) Human CD1d–LPC (cyan–yellow) is aligned with human CD1d–αGalCer shown in lavender (PDB ID: 1ZT4) via their main-chain CA carbons of the heavy chains. The ∼2.1-Å shift in the CD1d–LPC α1 helix main chain relative to CD1d–αGalCer structure as well as the relative positioning of the bound lipid ligands is shown. (C) Superposition of published mouse CD1d α1 and α2 platform domains aligned through the graphics program Pymol. CD1d structures are shown as cartoon loop format and are derived from the following PDB IDs: 3MA7, EILP, 3ILQ, 3GO8, 3GML, 3GMN, 3GMO, 3GMP, 3GMQ, 3GMR, 2Q7Y, 2GAZ, 2FIK, 2AKR, 1Z5L and 1ZHN.