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. 2012 Mar 23;13(5):455–461. doi: 10.1038/embor.2012.37

Figure 4.

Figure 4

Behavioural rhythms and light-induced phase and period responses in Jnk3-deficient mice. Double-plotted spontaneous locomotor activity rhythms of representative wild-type (A) and Jnk3-deficient (B) mice. Horizontal black and white zones above each actograph indicate the dark and light phase in light–dark (LD) cycle, respectively. Yellow triangles indicate time points when the light pulse was given (30 min, 300 lux). Oblique red lines are the regression lines fitted to the consecutive activity onsets before and after the light pulse. (C) Circadian periods of the behaviour rhythms under constant darkness (DD) condition in Jnk3-deficient (n=22, black columns) and wild-type mice (n=16, open columns). (D) Phase response to brief light pulses (300 lux, 30 min) given at six different circadian times (CT)s. Phase-advance and phase-delay shifts are expressed in positive and negative values, respectively. (E) Changes of circadian periods after the brief light pulses. Lengthening and shortening of the circadian period are expressed in negative and positive values, respectively. (F) Changes in circadian periods under constant light (LL) conditions in Jnk3-deficient (n=5) and wild-type mice (n=5). (C–F) Data are means with s.d. Single and double asterisks indicate P<0.05 and P<0.01, respectively (post hoc Tukey Krammer test, versus wild type). JNK, c-Jun N-terminal kinase.