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. 2012 May;139(5):359–370. doi: 10.1085/jgp.201210789

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© 2012 Jih et al.

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Figure 4. — ADP competes with PPi for state X. (A–C) Macroscopic current of WT-CFTR was activated by ATP to a steady state before switching the ligand to a 1-s pulse of 10 mM PPi in the presence of 1 mM (A), 2 mM (B), or 10 mM (C) ADP. (D) Summary of the proportion of locked-open currents (I LO) relative to ATP-activated currents (I ATP) at different ADP concentrations (mean ± SEM). *, P < 0.05 compared with 0 ADP.