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. 2012 May 4;3:118. doi: 10.3389/fphys.2012.00118

Figure 2.

Figure 2

L-type Ca2+ current in disaggregated cardiomyocytes from wild-type (WT) versus KChIP2−/−. ICa,L was recorded at 37°C in left ventricular cardiomyocytes as the current fraction sensitive to 300 μM Cd2+, as described by Sah et al. (2002) with minor modifications. (A) Representative current traces of WT and KChIP2−/− (inset, voltage protocol). (B) Mean peak current densities show a decreased ICa,L in KChIP2−/− cardiomyocytes. (C) No changes were found in the steady-state inactivation of ICa,L in WT versus KChIP2−/− cardiomyocytes (inset, voltage protocol). Data are reported as mean ± SEM. Statistical significance was evaluated by ANOVA followed by Newman–Keuls’ post hoc test where appropriate. *p < 0.05. Comparable data have been published previously by Thomsen et al. (2009c).