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Comparison of the Cwc2 TlS11d ZnF. (A) Superposition of a CCCH-type ZnF domain of TIS11d on Cwc2. Cwc2 residues potentially involved in binding RNA and the four residues coordinated by zinc in the two proteins are shown and labelled. (B) Recognition of an AU-rich RNA element by the ZnF domain of TIS11d (pdb 1RGO) (Hudson et al, 2004), in the same orientation. The aromatic residues from TIS11d involved in stacking interactions with the bases are depicted as sticks.
