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. 2012 Mar 20;31(9):2067–2075. doi: 10.1038/emboj.2012.67

Figure 1.

Figure 1

Bulge SC contribution to the sebaceous lineage. (A) Scheme highlighting the different epidermal SC populations found in the skin epidermis: the IFE SC (shown in blue), the bulge SC (Bu in red), the isthmus SC (Is in green) and the junctional SC (JZ in yellow). (B) Lineage tracing experiments have shown that IFE is maintained independently of the HF by the presence of number small unit of proliferation. (C) Lineage tracing of bulge SC using K15CREPR, Lgr5CREER and K19CREER demonstrate their ability to contribute to the homeostasis of the hair follicle but not the SG or the IFE. (D) Lgr6 lineage tracing show the long-term renewal of Lgr6+ isthmus cells and their contribution to the sebaceous lineage. (E) The recent study of Petersson and colleagues using a new K15CreER shows the potential contribution of bulge SCs to the SG homeostasis.