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. 2001 May 8;98(11):6138–6143. doi: 10.1073/pnas.111139598

Figure 4.

Figure 4

The extracellular domain of the ovIFNAR2 subunit (R2E) has intrinsic AV activity. (A) ovIFN-τ4 was diluted from left to right in a 1:3 series. (B) Thrombin-cleaved GST-R2E was diluted from top to bottom in a 1:3 series. (C) The treatments were combined (ovIFN-τ4, left to right; R2E, top to bottom). Protected cell monolayers take up the Gentian violet stain. (D) A comparison of the effects of R2E, GST-R2e, R1e, and ovIFN-τ4 on MDBK cells (Top), mouse L929 cells (Middle), and L929 cells stably transfected with a chimeric receptor (R2C) containing the extracellular domain of ovIFNAR2 (19) and the intracellular domain of huIFNAR2c (24) (Bottom).