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. Author manuscript; available in PMC: 2012 May 4.
Published in final edited form as: Transplant Proc. 2009 Jul-Aug;41(6):2601–2606. doi: 10.1016/j.transproceed.2009.06.025

Figure 3. In vivo blockade of KCa3.1 and Kv1.3 inhibits mononuclear cell infiltration into renal allografts in vivo.

Figure 3

(A) Left panel: Photographs display representative areas of PAS-stained cross sections from rat kidney grafts seventeen days after transplantation (magnification ×400). Note reduced tubulointerstitial infiltrates in allografts from TRAM-34/ShK- and CsA-treated animals compared to vehicle-treated controls. Right panel: Histopathological evaluation of cross sections from kidney allografts with TRAM-34/ShK (n=7), CsA (n=5), or vehicle (Ve; n=7) treatment. Non-treated animals with isografts (Iso; n=3) served as negative controls. (B) Left panel: Photographs display representative areas of kidney graft cross sections stained for T-cell marker CD43 (W3/13 Ab) seventeen days after transplantation (magnification ×400). Right panel: Histopathological evaluation of cross sections. (C) Histopathological evaluation of sections stained for cytotoxic T-cell marker CD8 (MRC OX-8Ab). Note that CD8+ T-cells were not detectable in isografts. (D) Histopathological evaluation of CD68+ macrophage infiltration (ED1Ab) . Data are given as mean ± SEM; *P<0.05, **P<0.01.