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. Author manuscript; available in PMC: 2013 May 1.

Published in final edited form as: Clin Immunol. 2012 Feb 10;143(2):188–199. doi: 10.1016/j.clim.2012.01.019

Lack of inhibition by simvastatin on LPS-stimulated IL-6 secretion by gingival fibroblasts. A. The effect of simvastatin (Simv) on LPS-stimulated IL-6 mRNA expression by U937 cells and gingival fibroblasts. U937 cells and gingival fibroblasts were treated with 100 ng/ml of LPS in the absence or presence of 1 or 10 µM of simvastatin for 4 h for U937 cells and 2 h for fibroblasts and IL-6 mRNA was quantified using real-time PCR. B. The effect of simvastatin on LPS-stimulated IL-6 secretion by U937 cells and gingival fibroblasts. U937 cells or gingival fibroblasts were treated with or without 100 ng/ml of LPS in the absence or presence of 1 or 10 µM of simvastatin for 24 h. After the treatment, IL-6 in culture medium was quantified using ELISA. The data (mean ± SD) presented are representative of three independent experiments with similar results.

Lack of inhibition by simvastatin on LPS-stimulated IL-6 secretion by gingival fibroblasts. A. The effect of simvastatin (Simv) on LPS-stimulated IL-6 mRNA expression by U937 cells and gingival fibroblasts. U937 cells and gingival fibroblasts were treated with 100 ng/ml of LPS in the absence or presence of 1 or 10 µM of simvastatin for 4 h for U937 cells and 2 h for fibroblasts and IL-6 mRNA was quantified using real-time PCR. B. The effect of simvastatin on LPS-stimulated IL-6 secretion by U937 cells and gingival fibroblasts. U937 cells or gingival fibroblasts were treated with or without 100 ng/ml of LPS in the absence or presence of 1 or 10 µM of simvastatin for 24 h. After the treatment, IL-6 in culture medium was quantified using ELISA. The data (mean ± SD) presented are representative of three independent experiments with similar results.