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Cadherin cleavage. Classical cadherins are linked to the actin cytoskeleton via β-catenin (β) and α-catenin (α). E- and N-cadherin cleavage by an α-secretase produces the shed s-Cad subunit and a membrane tethered Cad/CTF1. Subsequent γ-secretase cleavage produces Cad/CTF2 that is released from the plasma membrane (PM) and is capable of translocating to the nucleus. Caspase 3 cleavage generates an even smaller fragment of E-cadherin, Cad/CTF3.
