Figure 8.

RhoB is critical for the radio response of tumor xenografts. Severe combined immunodeficient mouse tumor xenografts were generated by s.c. injection of 10⁷ transformed +/− or −/− cells into opposite thighs of the same mouse. The next day, the animals were divided into control or treatment groups and the latter group was irradiated at the injection site with a dose of 15 Gy. Tumor growth was monitored at various times afterward. Each point represents the mean and SE of the tumor volume as calculated by the formula volume = width² × length × 0.52.