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. 2012 Feb 8;9:29. doi: 10.1186/1742-2094-9-29

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Copyright ©2012 Kaushansky et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Histopathology of PLP-induced EAE in HLA DQB1*0602 Tg mouse. Samples were taken on day19 after immunization. Panel (A) shows the spinal cord, (B) the cerebellum and (C) the optic nerve. The sections were stained with hematoxylin & eosin (a), Luxol fast blue for myelin. (b) Bieschowsky silver impregnation for axons (c) and by immunocytochemistry for CD3 (d), and Mac-3 (e). Note the unusually profound inflammation in the cortex and optic nerve. Original magnifications: A and B: × 25; C: × 100.