Table 5. Compounds 13 and 33 exert synergy with fluconazole against in vitro Candida albicans biofilm^*.

Compound	EC25	EC25 with Fluconazole	FIC
13	6.30±0.00	1.20±0.57	0.26±0.09
33	4.71±2.25	1.20±0.57	0.32±0.00

^*FIC index = [EC25(A in combination)]/[EC25(A alone)]+[EC25(B in combination)]/[EC25(B alone)], where A is compound 13 or 33 and B is fluconazole. An index of <0.5 indicates synergism. The results are averages ± SD of two independent experiments.