. 2012 May 4;7(5):e36264. doi: 10.1371/journal.pone.0036264

Table 5. Association of mitochondrial SNPs with weight¹ using population-based association analysis².

Weight	SNP	Set1					Set2					Set3
		R ²	t	P	P_empirical	FDR–BH	R ²	t	P	P_empirical	FDR–BH	R ²	t	P	P_empirical	FDR–BH
Weight2	mtSNP6	0.05	−1.3	0.177	0.181	0.21	0.12	−2.1	0.041^*	0.0417^*	0.11	0.05	−1.4	0.151	0.15	0.22
	mtSNP8	0.11	−2.1	0.039^*	0.039^*	0.21	0.16	−2.6	0.013^*	0.0134^*	0.11	0.03	−1	0.302	0.3	0.31
	mtSNP21	0.11	−2.1	0.039^*	0.039^*	0.21	0.16	−2.6	0.013^*	0.013^*	0.11	0	−0.29	0.772	0.773	0.77
Weight3	mtSNP8	0.1	−2	0.052	0.053	0.34	0.09	−1.9	0.055	0.057	0.11	0.21	−3.1	0.004^**	0.004^**	0.05
	mtSNP21	0.02	−0.8	0.393	0.39	0.43	0.11	−1.9	0.062	0.063	0.11	0.25	−3.4	0.002^**	0.002^**	0.04^*
Weight4	mtSNP1	0.01	−0.5	0.57	0.568	0.93	0.07	−1.6	0.106	0.105	0.18	0.12	−2	0.045^*	0.044^*	0.09
	mtSNP4	0.01	−0.5	0.57	0.568	0.93	0.07	−1.6	0.106	0.105	0.18	0.12	−2	0.045^*	0.044^*	0.09
	mtSNP7	0.01	−0.5	0.57	0.568	0.93	0.06	−1.4	0.145	0.143	0.2	0.13	−2.1	0.041^*	0.040^*	0.09
	mtSNP8	0.13	−2.3	0.022^*	0.022^*	0.53	0.22	−3.1	0.003^**	0.003^**	0.03^*	0.12	−2.1	0.041^*	0.041^*	0.09
	mtSNP15	0.01	−0.5	0.57	0.568	0.93	0.07	−1.6	0.106	0.105	0.18	0.12	−2.1	0.045^*	0.044^*	0.09
	mtSNP16	0	−0.3	0.766	0.763	0.93	0.04	−1.3	0.192	0.191	0.2	0.14	−2.2	0.038^*	0.038^*	0.09
	mtSNP21	0.07	−1.6	0.114	0.113	0.93	0.27	−3.4	0.001^**	0.002^**	0.03^*	0.13	−2.2	0.037^*	0.036^*	0.09

Body weight was recorded on each animal at approximately 7 (Weight2), 9 (Weight3) and 12 (Weight4) months post-hatching.

Population-based association analysis was performed with program PLINK version 1.07 [22]. From 40 full-sib families each with ∼17 progeny, a sibling was randomly sampled from each family to generate a population-based sample of n = 40 unrelated individuals; we repeated the random sampling to develop three sets of unrelated individuals. Here, t is the t-statistic for regression of phenotype on allele count (by.x); R2 is the square of the multiple correlation coefficient which measures the proportion of total variation explained by the regression by.x; P is the asymptotic P-value for t-statistic; the empirical P-value was estimated using 20,000 permutations; and FDR-BH is the false discovery rate [27].

^**

indicates significance at P<0.01.

indicates significance at P<0.05.

Table 5. Association of mitochondrial SNPs with weight1 using population-based association analysis2.

Table 5. Association of mitochondrial SNPs with weight¹ using population-based association analysis².