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. 2012 May 4;7(5):e36412. doi: 10.1371/journal.pone.0036412

Figure 1. Schematic representations of the full-length CEA and CEA splice variant.

Figure 1

A, intron and exon structure of the full-length CEA and CEA splice variant transcripts. The full-length CEA transcript (NCBI accession number NM002483) consists of 10 exons and 9 introns as shown schematically. The transcript corresponding to the CEA splice variant (NCBI accession number CR749337) removes exons 3 and 4 and a portion of exon 2 to create an alternative splice variant CEA transcript with 8 exons and 7 introns. Boxes indicate exons and lines indicate introns (not drawn to scale). B, protein domain structure of the translated full-length and splice variant transcripts of CEA. The mature full-length CEA is composed of one N-terminal domain and six IgC-like domains denoted A1, B1, A2, B2, A3, and B3. The gray bar represents the GPI linkage of the proteins to the plasma membrane shown as two parallel vertical black lines.