Table 2. Pharmacokinetic parameters of MDMA, MDA, HMMA, and duloxetine.
| Cmax (ng/ml) | Tmax (h) | T1/2 (h) | AUC0-6 (ng/ml h) | AUC(0-∞) (ng/ml h) | ||
| MDMA | ||||||
| Placebo-MDMA | 221.31±11.63 | 2.34±0.19 | 8.17±0.74 | 952.75±45.89 | 2908.55±275.64 | |
| Duloxetine-MDMA | 253.63±13.60** | 2.66±0.29 | 7.14±0.40 | 1106.87±57.22** | 2915.28±154.27 | |
| MDA | ||||||
| Placebo-MDMA | 11.75±0.70 | 5.50±0.22 | – | 46.60±3.02 | – | |
| Duloxetine-MDMA | 10.67±0.72 | 5.25±0.30 | – | 41.95±3.38 | – | |
| HMMA | ||||||
| Placebo-MDMA | 3.36±0.34 | 1.84±0.17 | – | 13.57±1.58 | – | |
| Duloxetine-MDMA | 2.00±0.38*** | 1.89±0.25 | – | 8.14±1.45*** | – | |
| Duloxetine | ||||||
| Duloxetine-placebo | 106.77±10.25 | 5.14±0.29 | 10.97±1.04 | 799.88±74.40 | 1960.18±229.54 | |
| Duloxetine-MDMA | 111.69±7.06 | 5.95±0.39 | 11.37±1.43 | 814.31±52.73 | 2189.45±297.99 | |
Cmax, maximum plasma concentration; Tmax, time from drug administration to maximum plasma concentration; AUC0-∞, area under concentration-time curve extrapolated to infinity. HMMA, 4-hydroxy-3-methoxymethamphetamine; MDMA, 3,4-methylenedioxymethamphetamine; MDA, 3,4-methylenedioxyamphetamine. **p<.01, ***p<.001, vs. Placebo-MDMA. Values are mean±SEM (n = 16).