Table 4. Binding affinities to human monoamine transporters.
SERT | NET | DAT | |
MDMA | 13.3±0.47 | 22.4±14.6 | 6.52±2.24 |
MDA | 18.7±2.76 | 17.8±4.06 | 26.4±4.24 |
Duloxetine | 0.005±0.002 | 0.07±0.05 | 0.70±0.07 |
Reboxetine | 0.24±0.02 | 0.015±0.01 | 16.2±4.91 |
Citalopram | 0.005±0.001 | 5.06±3.00 | 21.4±10.5 |
Indatraline | 0.02±0.008 | 0.03±0.02 | 0.01±0.01 |
Paroxetine | 0.004±0.001 | 0.42±0.17 | 0.77±0.18 |
Values are mean±SD of Ki (µM) (n≥3). Radioligands were 3[H]citalopram, 3[H]nisoxetine, and 3[H]-WIN35,428 for SERT, NET, and DAT, respectively.