Table 5. Monoamine transport inhibition.
SERT | NET | DAT | |
Ki (µM) (95% CI) | Ki (µM) (95% CI) | Ki (µM) (95% CI) | |
MDMA* | 1.40 (1.00–1.96) | 0.470 (0.334–0.598) | 16.7 (11.5–24) |
MDA* | 2.41 (1.49–3.92) | 0.341 (0.253–0.461) | 11 (7.5–17) |
Duloxetine | 0.050 (0.04–0.07)* | 0.126 (0.099–0.161)* | 2.26 (0.7–3.8)# |
Reboxetine | 2.07 (1.4–2.6)# | 0.036 (0.030–0.044)* | 16.4 (11.5–25.2)# |
Citalopram* | 0.045 (0.037–0.057) | >20 | >20 |
Indatraline# | 0.09 (0.06–0.12) | 0.043 (0.03–0.06) | 0.025 (0.01–0.04) |
Paroxetine# | 0.014 (0.01–0.02) | 1.12 (0.03–1.7) | 4.83 (2.4–7.3) |
method A; #method B; 95% CI, 95% confidence interval; values are significantly different (p<0.05) if 95% CI do not operlap.