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. 2012 May 4;7(5):e36544. doi: 10.1371/journal.pone.0036544

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Sztal et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Phylogenetic analysis of Cyp301A1 and Cyp301B1 in the insect species. Values shown represent 1000 bootstrapping values. D. melanogaster (D.mel) Cyp49A1 was used as an outgroup. D.ere = D. erecta, D.sec = D. sechellia, D.sim = D. simulans, D.yak = D. yakuba, D.ana = D. ananassae, D.per = D. persimilis, D.pse = D. pseudoobscura, D.gri = D. grimshawi, D.vir = D. virilis, D.moj = D. mojavensis, D.wil = D. willistoni, A.gam = A. gambiae, N.vit = Nasonia vitripennis, A.mel = Apis mellifera T.cas = Tribolium castaneum, B.mor = Bombyx mori, P.hum = Pediculus humanis. (B) Alignment of the heme-binding domain of Cyp301A1 and Cyp301B1 from representative insect species. Conserved residues in the heme-binding domain consensus sequence (PxxxGxxxCxG) are highlighted in blue. The conserved Phenylalanine (F) in the second position (highlighted in green) in Cyp301B1 orthologs is changed to a Tyr (Y) (highlighted in red) in all Cyp301A1 orthologs.