Figure 1. In vivo effects of treatment with [⁴⁴AANA⁴⁷]-CCL5 on acute liver cell injury.

(A) Mice treated with [⁴⁴AANA⁴⁷]-CCL5 have reduced serum transaminases 48 hours after CCl₄ application compared to vehicle treated mice. (B) Reduced liver cell damage is also evidenced by reduced necrotic areas 48 h hours after injury (HE staining, ×100). (C) The ameliorated damage after 48 h in [⁴⁴AANA⁴⁷]-CCL5 treated mice is preceded by a significantly reduced infiltration of CD45+ immune cells. (D) Reduced inflammatory liver damage in [⁴⁴AANA⁴⁷]-CCL5 is also associated with significantly repressed pro-inflammatory mRNA expression (black bars: [⁴⁴AANA⁴⁷]-CCL5, open bars: vehicle). * P<0.05, ** P<0.01.