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. 2012 May 4;7(5):e36594. doi: 10.1371/journal.pone.0036594

Figure 7. Idarubicin induces STAT1-dependent gene expression.

Figure 7

U3A-STAT1 and U3A (STAT1-null) cells were treated with idarubicin for 1.5 h followed by IFN-β for 12 h and then determination of OAS1 and GBP1 mRNA levels using real-time quantitative PCR assay. Overall significance for idarubicin dose p<0.0001, IFN-β dose p<0.0001, and interaction p<0.0001. The p-values for individual comparisons (vs 0 idarubicin control) are from Bonferroni post-tests from two-way ANOVA (idarubicin x IFN dose). Symbols: * p<0.01, ** p<0.001.