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. 2012 May 4;7(5):e36652. doi: 10.1371/journal.pone.0036652

Figure 6. cAMP levels in Hela cells in each group and PDE inhibition activities in vitro.

Figure 6

A) cAMP concentrations in Hela cells in each group at 12 and 24 h. CON, control; HF, 20 µM HF group; FP, 20 µM FP group. B) Histogram representing inhibitory effects of FP and HP on PDE and CaM-activated PDE1 activity. C) Inhibitory effects of FP and HP on CaM-activated PDE1 activity. D) Inhibitory effects of FP and HP on PDE activity from bovine brain. Values are given as mean ± SE; RLU (relative light units) on the y axes of panels C and D is positively related with CaM-activated PDE1 or PDE activities. The IC50 was calculated by using a sigmoidal dose-response (variable slope) equation analysis. & p<0.01 versus control group; *p<0.001 versus HF group; # p<0.01 versus control group; $ p<0.01 versus 24 h FP group.