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. 2012 May 4;7(5):e36704. doi: 10.1371/journal.pone.0036704

Table 1. Validation of the differential expression of selected genes in ILK-deficient epidermis.

ILKdeficient/ILKexpressing (fold change)
Class Gene Gene Name Microarray qPCR
Hair follicle
Dsg4 Desmoglein 4 −7.9 −18.2
Krt31 Keratin 31 −16.1 −28.6
Krtap3-3 Keratin-associated protein 3-3 −18.4 −7.8
Gpcr5d G protein-coupled receptor family C, Group 5, member D −14.7 −4.9
Tchhc Trichohyalin −16.9 −28.0
Keratinocyte Differentiation; Psoriasis
Crnn Cornulin −8.6 −15.5
S100A3 S11 calcium-binding protein A3 −7.5 −21.9
Psors1c2 Psoriasin (S100 A7) −4.5 −7.6
Growth factor pathways
Tgfb2 Transforming growth factor-ß2 2.9 3.1
Ltbp1 Latent TGF-ß binding protein 1 2.3 1.9
Igf1r Insulin-like growth factor receptor 1 2.0 2.0
Ctgf Connective tissue growth factor 2.7 3.7
Wnt pathway
Sfrp2 Secreted frizzle-related protein 2 3.5 2.6
Lgr5 Leucin-rich repeat containing GPCR5 3.1 8.0
Hedgehog Pathway
Gli1 GLI family zinc finger 1 1.9 4.5
Gli2 GLI family zinc finger 2 1.8 5.1
Ptch2 Patched homolog 2 2.3 5.2
Bmp7 Bone morphogenetic protein 7 1.5 3.1
Miscellaneous
Hr Hairless 2.2 2.6
Tyr Tyrosinase 2.9 2.0
Rhoc Ras homolog gene family member C 2.5 3.9