Table 3. Expression of synovial phenotypic and vascular markers in patients who fulfilled 2010 ACR/EULAR criteria for RA at baseline subclassified according to fulfillment of 1987 ACR criteria at baseline and after follow up.
| RA 2010 ACR/EULAR (n = 46) | P-value | |||
| RA-RA 1987 (n = 25) | UA-RA 1987 (n = 8) | UA-UA 1987 (n = 13) | ||
| CD3 (count/mm2) | 327 (867) | 107 (157) | 304 (882) | 0.28 |
| CD55 (count/mm2) | 1,163 (1,273) | 1,514 (1,914) | 963 (1,116) | 0.62 |
| CD68L (count/mm2) | 256 (458) | 139 (150) | 229 (456) | 0.81 |
| CD68SL (count/mm2) | 491 (1,611) | 362 (476) | 570 (1,211) | 0.91 |
| CD22 (count/mm2) | 198 (389) | 233 (286) | 407 (598) | 0.58 |
| CD138 (count/mm2) | 191 (585) | 30 (329) | 76 (409) | 0.48 |
| Tryptase (count/mm2) | 337 (311) | 419 (549) | 221 (587) | 0.61 |
| vWF (IOD/mm2) | 205,558 (161,492) | 93397(181,405) | 224,825 (194,340) | 0.21 |
| VEGF (IOD/mm2) | 63,659 (96,163) | 57,865 (59,901) | 55,365 (140,674) | 0.99 |
| VCAM-1 (IOD/mm2) | 195,424 (302,882) | 96,545 (175,238) | 184,647 (322,252) | 0.33 |
Values are presented as median (interquartile range). A Kruskal-Wallis test was used to compare the different diagnostic groups; a P-value of <0.05 was considered statistically significant. RA = rheumatoid arthritis. UA = undifferentiated arthritis. CD3 refers to T cells; CD55– fibroblast-like synoviocytes; CD68– macrophages; CD22– B cells; CD138– plasma cells; tryptase – mast cells. L = intimal lining layer; SL = synovial sublining; vWF = von Willebrand factor; VEGF = vascular endothelial growth factor; VCAM-1 = vascular cell adhesion molecule-1. IOD = integrated optical density.