Glutathione involvement in the cytotoxicity of 56MESS. a The growth inhibition of the gsh1Δ mutant under 56MESS treatment. Square, untreated; multiplication symbol, 2.5 mM 56MESS; circle, 5.0 mM 56MESS. b Effects of supplementing glutathione into L1210 cell culture on the 56MESS’ cytotoxicity. Square, 1.2 mM GSH only; cross, control; circle, 0.045 mM 56MESS with 0.6 mM GSH; multiplication symbol, 0.045 mM 56MESS with 1.2 mM GSH; triangle, 0.045 mM 56MESS only