Table 1.

IC₅₀ (μM) values of honokiol analogs in human cancer cell lines (24 and 72 h exposure)^a.

	UACC903		A549		HT-29
analog	24h	72h	24h	72h	24h	72h
1	37.68±27.86	24.13±19.75	1.56±0.88	1.24±0.77	22.45±17.20	14.13±10.84
2	2.98±1.78	1.29±0.80	1.73±0.88	1.04±0.68	3.99±2.62	1.87±1.23
3	3.94±4.28	2.93±1.73	1.74±1.10	1.25±0.78	16.89±12.57	11.39±9.14
4	3.05±1.83	1.39±0.84	2.47±1.32	1.99±1.09	3.19±1.78	2.00±1.27
5	29.04±22.37	24.66±18.26	11.29±7.78	6.28±4.42	16.24±13.30	11.50±8.92
6	22.28±15.92	17.39±12.60	2.04±1.15	1.08±0.66	17.38±14.02	12.37±10.31
Honokiol	7.45±5.28	5.10±3.68	12.51±7.94	7.75±4.96	23.85±18.04	13.24±10.66

^aCells were incubated in the presence or absence of honokiol analogs at different concentrations (μM). Effective concentration of honokiol analogs that inhibited cell growth to 50% of control (IC₅₀) in three different cancer cell lines was determined (GraphPad Prism version 4 for Windows) using the MTS assay. Values are given as mean ± SD of three separate assays.