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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Semin Cell Dev Biol. 2011 Oct 19;23(3):269–274. doi: 10.1016/j.semcdb.2011.10.009

Fig. 3.

Fig. 3

Connection between editing and modification. Following import into the mitochondria of kinetoplasts (T. brucei and Leishmania), tRNAs are edited and thiolated. In T. brucei thiolation at the unusual position 33 serves as a negative determinant for editing. In marsupials editing creates the recognition motif for the enzyme guanosine transglycosylase (GTG) required for the biosynthesis of the nucleotide queosine (Q). Mtu1, Nfs and Isd11 refer to factors of the FeS-cluster biosynthetic pathway that also required for thiolation.