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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Jan 9;1819(6):538–545. doi: 10.1016/j.bbagrm.2011.12.011

Figure 2.

Figure 2

Splicing regulation of the RPL30 transcript. The RPL30 gene encodes the essential protein L30. Pre-mRNA splicing contributes to maintaining the protein levels by an autoregulatory feedback loop. The newly made L30 (shown as a ball) must be transported to the nucleolus to join ribosome biosynthesis (top). However, if that is not possible (conditions of excess L30), the protein binds its own pre-mRNA. This prevents RPL30 splicing and triggers the transport and decay of the pre-mRNA in the cytoplasm. The choice for L30 between either ribosome biosynthesis or splicing control (orange square) has been depicted in the nucleus, but its mechanism and location is unknown (for simplicity reasons the binding site of L30 is shown entirely in exon 1, although it includes the 5' ss).