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. Author manuscript; available in PMC: 2013 May 15.
Published in final edited form as: J Immunol. 2012 Apr 13;188(10):4866–4875. doi: 10.4049/jimmunol.1200402

Figure 3. Persistent antigen alters canonical IEL phenotype.

Figure 3

(A) C57Bl/6J mice were infected with the Armstrong (cleared) or Cl-13 (chronic) strains of LCMV. 21 days later, lymphocytes were isolated from spleen and SI IEL (plots gated on CD8α+ lymphocytes). Percent of CD103+ cells among H-2Db/gp33 tetramer+ (upper right) or tetramer- (lower right) is indicated. (B) Mean percent of H-2Db/gp33 tetramer+ IEL that were CD103+, n=5. ***p<0.001, Student's unpaired t test. Error bars indicated SEM. (C) Naïve OT-I were transferred to ovalbumin bearing 232–4 mice and 150 days later isolated SI IEL were examined for expression of CD103 (black histogram gated on OT-I, gray histogram gated on CD8α+ lymphocytes). All plots are representative of at least three mice per experiment and each experiment was performed at least twice.