Figure 5. PD-1 deficiency exacerbates experimental autoimmune myocarditis.

WT, Pd1^−/− or Pdl1^−/− BALB/c mice were immunized at day 0 and day 7 with CFA/γ-myosin heavy chain peptide, and sacrificed at day 21. Representative sections of H&E stained sections of heart tissue are shown (A). Sections were scored for histopathology (B), and troponin I levels were measured in serum collected at sacrifice (C). Data are mean ± S.E.M. of 7–10 mice per group. * P<0.05, ** P<0.01 *** P< 0.001